2009 Fiscal Year Final Research Report
Computational design and development of new functional ate complexes and its practical applications to organic transformations
| Project/Area Number |
19685005
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
UCHIYAMA Masanobu The Institute of Physical and Chemical Research, 内山機能元素化学研究室, 准主任研究員 (00271916)
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| Project Period (FY) |
2007 – 2009
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| Keywords | アート錯体 / 化学選択性 / 分子変換 |
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| Research Abstract |
We have developed new zincate reagents with high functional group tolerance. A novel zincate complex consisting of isopropyl ligands and magnesium salt as a counter cation ((iPr)_nZn)(MgCl)_<n-2>) was designed. Reactions of highly functionalized aromatic iodides with the zincate resulted in halogen-metal interconversion with excellent reactivity and high ligand selectivity. We have also developed a new organosilyl zincate complex. The reagents were found to be useful for novel silyl-metalation reactions. The mechanism of these chemical reactions was fully analyzed on the basis of spectroscopic techniques and theoretical calculations. The chemical reactions we developed would offer a new synthetic approach for preparing organic molecules for applications in various fields such as material sciences, biotechnology, and organic syntheses.
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[Journal Article] Deprotonative Metalation of Functionalized Aromatics Using Mixed Lithium-cadmium, Lithium-indium, and Lithium-Zinc Species2009
Author(s)
Sne'garoffK., 'Helgoual'ch J., Bentabed-Ababsa G., Nguyen T.T., Chevallier F., Yonehara M., Uchiyama M., Derdour A., Mongin F.
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Journal Title
Chem. Eur. J. 15
Pages: 10280-10290
Peer Reviewed
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[Journal Article] Effect of Periodic Replacement of the Heteroatom on the Spectroscopic Properties of Indole and Benzofuran Derivatives2009
Author(s)
Muranaka A., Yasuike S., Liu C., Kurita J., Kakusawa N., Tsuchiya T., Okuda M., Kobayashi N., Matsumoto Y., Yoshida K., Hashizume D., Uchiyama M.
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Journal Title
J. Phys. Chem. 113
Pages: 464-473
Peer Reviewed
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[Presentation]2007
Author(s)
古山渓行, 内山真伸
Organizer
日本化学会第87春季年会
Place of Presentation
吹田
Year and Date
20070300
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