2009 Fiscal Year Final Research Report
Catalytic Asymmetric Hydrogenation of Polycyclic Aromatic Compounds
| Project/Area Number |
19685008
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
KUWANO Ryoichi Kyushu University, 大学院・理学研究院, 教授 (20273477)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 触媒的不斉合成 / 水素化 / 芳香族化合物 / ナフタレン / キノリン / 光学活性化合物 / ルテニウム / テトラリン |
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| Research Abstract |
Hydrogenations of 2,6- or 2,7-disubstituted naphthalenes proceeded in high yields with high enantioselectivity in the presence of the ruthenium complex which was chelated with the optically active bisphosphine, PhTRAP. The catalytic asymmetric hydrogenation produced optically active tetralines with up to 92% ee. The chiral ruthenium catalyst is also effective for the hydrogenation of quinolines to give 5,6,7,8-tetrahydroquinolines selectively. The asymmetric hydrogenation proceeded with up to 84% ee.
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