2010 Fiscal Year Final Research Report
Control of nonlinear processes of protein solution and biological cells induced by focused femtosecond laser
| Project/Area Number |
19686007
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied optics/Quantum optical engineering
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| Research Institution | Nara Institute of Science and Technology (2008-2010)
Hamano Life Science Research Foundation (2007) |
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Principal Investigator |
HOSOKAWA Youchiroh Nara Institute of Science and Technology, 物質創成科学研究科, 特任准教授 (20448088)
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| Project Period (FY) |
2007 – 2010
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| Keywords | フェムト秒レーザー / 原子間力顕微鏡 / 蛋白質 / 細胞 / 衝撃波 |
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| Research Abstract |
When an intense infrared-femtosecond-laser is focused into biological materials, shockwave and cavitation bubble are generated at the laser focal point, in which an explosive morphological change of water is induced by an effective multiphoton absorption. I developed a new local force measurement system to estimate the impulsive force due to the shockwave and cavitation bubble generated in biological materials and elucidated time and spatial evolution of these phenomena. On the basis of this knowledge, new control and measurement methods of single cell or intracellular protein were devised.
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[Journal Article] Correlation between cell morphology and aggrecan gene expression level during differentiation from mesenchymalstem cells to chondrocytes.2008
Author(s)
M.Takagi, T.Kitabayashi, S.Koizumi, H.Hirose, S.Kondo, M.Fujiwara, K.Ueno, M.Hiroaki, Y.Hosokawa, H.Masuhara, S.Wakitani.
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Journal Title
Biotechnol.Lett. Vol.30
Pages: 1189-1195
Peer Reviewed
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[Journal Article] Correlation between cell morphology and aggrecan gene expression level during differentiation from mesenchymal stem cells to chondrocytes.2008
Author(s)
M.Takagi, T.Kitabayashi, S.Koizumi, H.Hirose, S.Kondo, M.Fujiwara, K.Ueno, M.Hiroaki, Y.Hosokawa, H.Masuhara, S.Wakitani.
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Journal Title
Biotechnol.Lett. Vol.30
Pages: 1189-1195
Peer Reviewed
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[Presentation] Photonics West LASE 20092009
Author(s)
Y.Hosokawa, K.Okano, H.Masuhara.
Organizer
Local force detection of femtosecond laser-induced stress wave using atomic force microscope
Place of Presentation
California USA
Year and Date
2009-01-24
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[Presentation] Photonics West BiOS 20082008
Author(s)
Y.Hosokawa, Y.Jiang, I.Oh, N.Takizawa, T.Uwada, K.Okano, H.Masuhara,
Organizer
Femtosecond laser manipulation techniques for individual patterning of biological micro-object
Place of Presentation
California USA
Year and Date
2008-01-19
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