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2009 Fiscal Year Final Research Report

Reconstruction of a bio-fluid dynamics model from the cellular level

Research Project

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Project/Area Number 19686016
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Fluid engineering
Research InstitutionTohoku University

Principal Investigator

ISHIKAWA Takuji  Tohoku University, 大学院・工学研究科, 准教授 (20313728)

Project Period (FY) 2007 – 2009
Keywords生物流体 / サスペンジョン / 微生物 / 赤血球 / 数理モデル
Research Abstract

We had developed a numerical model of microorganisms, red blood cells and cancer cells by 2008. We also tried to model biological reaction of cells. In 2009, we utilized these models and computed many body interactions of cells in a suspension. Then we compiled a database for the stress field, diffusion tensor under various conditions. We also developed a mathematical model of these tensor values under simplified conditions. Besides, we develop a numerical model to solve population of bacteria in the human intestine by combining the cellular level models and the macroscopic models. We established a base for the multi-scale and multi-physics simulation for the microbial flora in the intestine.

  • Research Products

    (42 results)

All 2010 2009 2008 2007 Other

All Journal Article (34 results) (of which Peer Reviewed: 34 results) Presentation (3 results) Book (3 results) Remarks (2 results)

  • [Journal Article] A three-dimensional particle simulation of the formation and collapse of primary thrombus2010

    • Author(s)
      H.Kamada, K.Tsubota, M.Nakamura, S.Wada, T.Ishikawa, T.Yamaguchi
    • Journal Title

      International Journal for Numerical Methods in Biomedical Engineering 26

      Pages: 488-500

    • Peer Reviewed
  • [Journal Article] ATP transport in saccular cerebral aneurysms at arterial bends2010

    • Author(s)
      Y.Imai, K.Sato, T.Ishikawa, A.Comerford, T.David, T.Yamaguchi
    • Journal Title

      Annals of Biomedical Engineering 38

      Pages: 927-934

    • Peer Reviewed
  • [Journal Article] Suspension biomechanics of swimming microbes2009

    • Author(s)
      T.Ishikawa
    • Journal Title

      Journal of the Royal Society Interface 6

      Pages: 815-834

    • Peer Reviewed
  • [Journal Article] Dancing Volvox : Hydrodynamic bound states of swimming algae2009

    • Author(s)
      K.Drescher, K.Leptos, I.Tuval, T.Ishikawa, T.J.Pedley, R.E.Goldstein
    • Journal Title

      Physical Review Letters 102

      Pages: 168101

    • Peer Reviewed
  • [Journal Article] Can temporal fluctuation in spatial wall shear stress gradient initiate a cerebral aneurysm? A proposed novel hemodynamic index, the gradient oscillatory number (GON)2009

    • Author(s)
      Y.Shimogonya, T.Ishikawa, Y.Imai, N.Matsuki, T.Yamaguchi
    • Journal Title

      Journal of Biomechanics 42

      Pages: 550-554

    • Peer Reviewed
  • [Journal Article] Hemodynamic analysis of micro-circulation in malaria infection2009

    • Author(s)
      H.Kondo, Y.Imai, T.Ishikawa, K.Tsubota, T.Yamaguchi
    • Journal Title

      Annals of Biomedical Engineering 37

      Pages: 702-709

    • Peer Reviewed
  • [Journal Article] Red blood cell motions in high-hematocrit blood flowing through a stenosed microchannel2009

    • Author(s)
      H.Fujiwara, T.Ishikawa, R.Lima, N.Matsuki, Y.Imai, H.Kaji, M.Nishizawa, T.Yamaguchi
    • Journal Title

      Journal of Biomechanics 42

      Pages: 838-843

    • Peer Reviewed
  • [Journal Article] Effects of unique biomedical education programs for engineers : REDEEM and ESTEEM projects2009

    • Author(s)
      N.Matsuki, M.Takeda, M.Yamano, Y.Imai, T.Ishikawa, T.Yamaguchi
    • Journal Title

      Advances in Physiology Education 33

      Pages: 91-97

    • Peer Reviewed
  • [Journal Article] An internet-based wearable watch-over system for elderly and disabled utilizing EMG and accelerometer2009

    • Author(s)
      M.Kishimoto, T.Yoshida, T.Hayasaka, D.Mori, Y.Imai, N.Matsuki, T.Ishikawa, T.Yamaguchi
    • Journal Title

      Technology and Health Care 17

      Pages: 121-131

    • Peer Reviewed
  • [Journal Article] Measurement of individual red blood cell motions under high hematocrit conditions using a confocal micro-PTV system2009

    • Author(s)
      R.Lima, T.Ishikawa, Y.Imai, M.Takeda, S.Wada, T.Yamaguchi
    • Journal Title

      Annals of Biomedical Engineering 37

      Pages: 1546-1559

    • Peer Reviewed
  • [Journal Article] Axisymmetric polydimethysiloxane microchannels for in vitro haemodynamic studies2009

    • Author(s)
      R.Lima, M.S.N.Oliveira, T.Ishikawa, H.Kaji, S.Tanaka, M.Nishizawa, T.Yamaguchi
    • Journal Title

      Biofabrication 1

      Pages: 035005(1-6)

    • Peer Reviewed
  • [Journal Article] A realistic simulation of saccular cerebral aneurysm formation : focussing on a novel haemodynamic index the gradient oscillatory number2009

    • Author(s)
      Y.Shimogonya, T.Ishikawa, Y.Imai, N.Matsuki, T.Yamaguchi
    • Journal Title

      International Journal of Computational Fluid Dynamics 23

      Pages: 583-593

    • Peer Reviewed
  • [Journal Article] Development of a biologically inspired locomotion system for a capsule endoscope2009

    • Author(s)
      D.Hosokawa, T.Ishikawa, H.Morikawa, Y.Imai, T.Yamaguchi
    • Journal Title

      International Journal of Medical Robotics and Computer Assisted Surgery 5

      Pages: 471-478

    • Peer Reviewed
  • [Journal Article] 準希薄微生物溶液における自己拡散シミュレーション-せん断流れの影響-2009

    • Author(s)
      石川拓司
    • Journal Title

      シミュレーション 1

      Pages: 60-65

    • Peer Reviewed
  • [Journal Article] Simulation of platelet adhesion and aggregation regulated by fibrinogen and von Willebrand factor2008

    • Author(s)
      D.Mori, K.Yano, K.Tsubota, T.Ishikawa, S.Wada, T.Yamaguchi
    • Journal Title

      Thrombosis and Haemostasis 99

      Pages: 108-115

    • Peer Reviewed
  • [Journal Article] In vitro blood flow in a rectangular PDMS microchannel : experimental observations using a confocal micro-PIV system2008

    • Author(s)
      R.Lima, S.Wada, S.Tanaka, M.Takeda, T.Ishikawa, K.Tsubota, Y.Imai, T.Yamaguchi
    • Journal Title

      Biomedical Microdevices 102

      Pages: 153-167

    • Peer Reviewed
  • [Journal Article] Coherent Structures in Monolayers of Swimming Particles2008

    • Author(s)
      T.Ishikawa, T.J.Pedley
    • Journal Title

      Physical Review Letters 100

      Pages: 088103

    • Peer Reviewed
  • [Journal Article] A rule-based computational study on the early progression of intracranial aneurysms using fluid-structure interaction : Comparison between straight model and curved model2008

    • Author(s)
      Y.Feng, S.Wada, T.Ishikawa, K.Tsubota, T.Yamaguchi
    • Journal Title

      Journal of Biomechanical Science and Engineering 3

      Pages: 124-137

    • Peer Reviewed
  • [Journal Article] Shear-induced fluid-tracer diffusion in a semi-dilute suspension of spheres2008

    • Author(s)
      T.Ishikawa, T.Yamaguchi
    • Journal Title

      Physical Review E 77

      Pages: 041402

    • Peer Reviewed
  • [Journal Article] Radial dispersion of red blood cells in blood flowing through glass capillaries : Role of Hematocrit andgeometry2008

    • Author(s)
      R.Lima, T.Ishikawa, Y.Imai, M.Takeda, S.Wada, T.Yamaguchi
    • Journal Title

      Journal of Biomechanics 41

      Pages: 2188-2196

    • Peer Reviewed
  • [Journal Article] Importance of parent artery geometry in intra-aneurysm hemodynamics studies2008

    • Author(s)
      K.Sato, Y.Imai, T.Ishikawa, N.Matsuki, T.Yamaguchi
    • Journal Title

      Medical Engineering & Physics 30

      Pages: 774-782

    • Peer Reviewed
  • [Journal Article] Inflow into saccular cerebral aneurysms at arterial bends2008

    • Author(s)
      Y.Imai, K.Sato, T.Ishikawa, T.Yamaguchi
    • Journal Title

      Annals of Biomedical Engineering 36

      Pages: 1489-1495

    • Peer Reviewed
  • [Journal Article] Low voltage pulses can induce apoptosis2008

    • Author(s)
      N.Matsuki, T.Ishikawa, Y.Imai, T.Yamaguchi
    • Journal Title

      Cancer Letters 269

      Pages: 93-100

    • Peer Reviewed
  • [Journal Article] Formation of saccular cerebral aneurysms may require proliferation of the arterial wall (Computational investigation)2008

    • Author(s)
      Y.Shimogonya, T.Ishikawa, Y.Imai, D.Mori, N.Matsuki, T.Yamaguchi
    • Journal Title

      Journal of Biomechanical Science and Engineering 3

      Pages: 431-442

    • Peer Reviewed
  • [Journal Article] Development of coherent structures in concentrated suspensions of swimming model micro-organisms2008

    • Author(s)
      T.Ishikawa, J.T.Locsei, T.J.Pedley
    • Journal Title

      Journal of Fluid Mechanics 615

      Pages: 401-431

    • Peer Reviewed
  • [Journal Article] Development of a wearable system module for monitoring physical and mental workloads2008

    • Author(s)
      S.Kim, H.Nakamura, T.Yoshida, M.Kishimoto, Y.Imai, N.Matsuki, T.Ishikawa, T.Yamaguchi
    • Journal Title

      Telemedicine and e-Health 14

      Pages: 939-945

    • Peer Reviewed
  • [Journal Article] Effect of the red blood cells on the primary thrombus formation2008

    • Author(s)
      D.Mori, K.Yano, K.Tsubota, T.Ishikawa, S.Wada, T.Yamaguchi
    • Journal Title

      Thrombosis Research 123

      Pages: 114-121

    • Peer Reviewed
  • [Journal Article] Numerical simulation of a low-hematocrit blood flow in a small artery with stenosis2007

    • Author(s)
      T.Ishikawa, N.Kawabata, Y.Imai, K.Tsubota, T.Yamaguchi
    • Journal Title

      Journal of Biomechanical Science and Engineering 2

      Pages: 12-22

    • Peer Reviewed
  • [Journal Article] Analysis of destruction process of the primary thrombus under the influence of the blood flow2007

    • Author(s)
      K.Yano, D.Mori, K.Tsubota, T.Ishikawa, S.Wada, T.Yamaguchi
    • Journal Title

      Journal of Biomechanical Science and Engineering 2

      Pages: 34-44

    • Peer Reviewed
  • [Journal Article] Effect of the wall motion on arterial wall shear stress2007

    • Author(s)
      T.Fukui, K.H.Parker, Y.Imai, K.Tsubota, T.Ishikawa, S.Wada, T.Yamaguchi
    • Journal Title

      Journal of Biomechanical Science and Engineering 2

      Pages: 58-68

    • Peer Reviewed
  • [Journal Article] Hydrodynamic interaction between two swimming bacteria2007

    • Author(s)
      T.Ishikawa, G.Sekiya, Y.Imai, T.Yamaguchi
    • Journal Title

      Biophysical Journal 93

      Pages: 2217-2225

    • Peer Reviewed
  • [Journal Article] The rheology of a semi-dilute suspension of swimming model micro-organisms2007

    • Author(s)
      T.Ishikawa, T.J.Pedley
    • Journal Title

      Journal of Fluid Mechanics 588

      Pages: 399-435

    • Peer Reviewed
  • [Journal Article] Diffusion of swimming model micro-organisms in a semi-dilute suspension2007

    • Author(s)
      T.Ishikawa, T.J.Pedley
    • Journal Title

      Journal of Fluid Mechanics 588

      Pages: 437-462

    • Peer Reviewed
  • [Journal Article] Orientational relaxation time of bottom-heavy squirmers in a semi-dilute suspension2007

    • Author(s)
      T.Ishikawa, T.J.Pedley, T.Yamaguchi
    • Journal Title

      Journal of Theoretical Biology 249

      Pages: 296-306

    • Peer Reviewed
  • [Presentation] Shear-induced fluid-tracer diffusion in a semi-dilute suspension of spheres, Bulletin of the American Physical Society2009

    • Author(s)
      T.Ishikawa, T.Yamaguchi
    • Organizer
      DFD 2009,Vol.54, No.19, p.293
    • Place of Presentation
      Minneapolis,米国
    • Year and Date
      2009-11-22
  • [Presentation] Diffusion in concentrated suspensions of biological cells, Computational Vision and Medical Image Processing - VipIMAGE 20092009

    • Author(s)
      T.Ishikawa
    • Organizer
      CRC press, pp.327-330
    • Place of Presentation
      Port,ポルトガル
    • Year and Date
      2009-10-15
  • [Presentation] Mixing of red blood cells in high hematocrit blood flow in micro-channels2009

    • Author(s)
      T.Ishikawa, H.Fujiwara, R.Lima, N.Matsuki, Y.Imai, T.Yamaguchi
    • Organizer
      Proc.3rd Switzerland-Japan Workshop on Biomechanics 2009, p.47
    • Place of Presentation
      Engelberg,スイス
    • Year and Date
      2009-09-02
  • [Book] Modelling in Medicine and Biology VIII(Microvascular disorders induced by malaria infected red blood cells : a computational mechanical study using the biological particle method)2009

    • Author(s)
      T.Yamaguchi, H.Kondo, Y.Imai, T.Ishikawa
    • Total Pages
      49-55
    • Publisher
      WIT press
  • [Book] Advances in Computational Vision and Medical Image Processing, Methods and Applications Series : Computational Methods in Applied Sciences, 13(Microscale Flow Dynamics of Red Blood Cells in Microchannels : An Experimental and Numerical Analysis)2008

    • Author(s)
      R.Lima, M.Nakamura, T.Omori, T.Ishikawa, S.Wada, T.Yamaguchi
    • Total Pages
      203-220
    • Publisher
      Springer
  • [Book] Bio-mechanisms of Swimming and Flying(Properties of a Semi-dilute Suspension of Swimming Micro-organisms)2007

    • Author(s)
      T.Ishikawa, T.Yamaguchi, T.J.Pedley
    • Total Pages
      17-28
    • Publisher
      Springer-Verlag
  • [Remarks] ホームページ等

  • [Remarks] 研究成果のホームページ

    • URL

      http://db.tohoku.ac.jp/whois/detail/5e15d83900e65b755d2af8dd6a078164.html

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Published: 2012-02-13   Modified: 2016-04-21  

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