2009 Fiscal Year Final Research Report
Structural studies on intramembrane cleaving proteases
| Project/Area Number |
19687004
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
NOGI Terukazu Osaka University, 蛋白質研究所, 助教 (40379102)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 構造生物学 |
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| Research Abstract |
In this project, we carried out structural and biochemical studies on bacterial intramembrane proteases so as to elucidate the molecular mechanism of the regulated intramembrane proteolysis (RIP). We succeeded in purifying one of the intramembrane proteases with high purity and stability. In addition, we have found that the extracellular region of proteases is involved in the interaction with the substrate in the course of RIP.
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