2009 Fiscal Year Final Research Report
Regulation of acquired immunity by thymus-specific proteasomes
| Project/Area Number |
19687009
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo (2008-2009)
Tokyo Metropolitan Organization for Medical Research (2007) |
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Principal Investigator |
MURATA Shigeo The University of Tokyo, 大学院・薬学系研究科, 教授 (20344070)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 免疫 / 胸腺 / プロテアソーム / ペプチド / 正の選択 |
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| Research Abstract |
The acquired immune system, which can defend against all sorts of pathogens, is established by adequate selection of immature T cells in the thymus. We have discovered a new protease complex that we named "thymoproteasome" that is expressed exclusively in the cortical thymic epithelial cells, which mediate "positive selection," a process where useful T cells are selected and survive. We have demonstrated that the thymoproteasome regulate the positive selection by producing a unique peptide repertoire and presenting it to developing T cells.
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[Journal Article] Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection.2009
Author(s)
Tu L, Moriya C, Imai T, Ishida H, Tetsutani K, Duan X, Murata S, Tanaka K, Shimokawa C, Hisaeda H, et al.
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Journal Title
Peer Reviewed
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[Journal Article] Exclusive expression of proteasome subunit {beta}5t in the human thymic cortex2009
Author(s)
Tomaru U, Ishizu A, Murata S, Miyatake Y, Suzuki S, Takahashi S, Kazamaki T, Ohara J, Baba T, Iwasaki S, et al.
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Journal Title
Blood 113
Pages: 5186-5191
Peer Reviewed
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[Journal Article] Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation2009
Author(s)
Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, et al.
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Journal Title
Nat Cell Biol 11
Pages: 123-132
Peer Reviewed
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[Journal Article] 17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse2009
Author(s)
Tokui K, Adachi H, Waza M, Katsuno M, Minamiyama M, Doi H, Tanaka K, Hamazaki J, Murata S, Tanaka F, et al.
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Journal Title
Hum Mol Genet 18
Pages: 898-910
Peer Reviewed
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[Journal Article] Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes2008
Author(s)
Yashiroda H, Mizushima T, Okamoto K, Kameyama T, Hayashi H, Kishimoto T, Niwa S, Kasahara M, Kurimoto E, Sakata E, et al.
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Journal Title
Nat Struct Mol Biol 15
Pages: 228-236
Peer Reviewed
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[Journal Article] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice2007
Author(s)
Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, et al.
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Journal Title
Cell 131
Pages: 1149-1163
Peer Reviewed
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