2009 Fiscal Year Final Research Report
Screening for targets of CDK/cyclin
| Project/Area Number |
19687012
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Nagoya University |
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Principal Investigator |
MIMURA Satoru Nagoya University, 大学院・理学研究科, 助教 (60432233)
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| Project Period (FY) |
2007 – 2009
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| Keywords | DNA複製 / ユビキチンリガーゼ / 細胞周期制御 |
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| Research Abstract |
CDK/cyclin regulates the progression of the eukaryotic cell cycle. To understand the function of CDK/cyclin, I investigated the regulation of DNA replication, which is regulated by CDK/cyclin activity. I found that an ubiquitin ligase, SCFDia2 localized at replication fork and regulates its progression, and that Cul8, which is also an ubiquitin ligase, forms varieties of protein complex and participates in the regulation of genome stability.
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Research Products
(11 results)
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[Journal Article] Non-SCF-type F-box protein Roy1/Ymr258c interacts with a Rab5-like GTPase Ypt52 and inhibits Ypt 52 function Mol.2011
Author(s)
Liu, Y., Nakatsukasa, K., Kotera, M., Kanada, A., Nishimura, T., Kishi., T., Mimura, S., Kamura, T.
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Journal Title
Biol. Cell 22
Pages: 1575-1584
Peer Reviewed
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[Journal Article] Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing.2010
Author(s)
Mimura, S., Yamaguchi, T., Ishii, S., Noro E., Katsura., T., Obuse, C., Kamura, T.
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Journal Title
J.Biol.Chem. 285
Pages: 9858-9867
Peer Reviewed
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