2009 Fiscal Year Final Research Report
The mechanism of multifunctional biological activity of Ganoderma lucidam with preventive effects of sex-hormone related disease
| Project/Area Number |
19688009
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
林産科学・木質工学
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| Research Institution | Kyushu University |
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Principal Investigator |
SHIMIZU Kuniyoshi Kyushu University, 大学院・農学研究院, 助教 (20346836)
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| Project Period (FY) |
2007 – 2009
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| Keywords | マンネンタゲ / 霊芝 / キノコ / 前立腺肥大症 / 骨粗鬆症 / トリテルペノイド / ganoderic acid DM |
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| Research Abstract |
The fungus Ganoderma lucidum (Reishi, Mannentake, or Lingzhi) has been used for centuries in East Asia to treat various human diseases. We investigated anti-androgen effect and the inhibitory effects of osteoclastic differentiation of triterpenoids isolated from G lucidum in vitro. Ganoderic acid DM showed the strongest 512-reductase inhibiting effect among the other ten triterpenoids. Also, ganoderic acid DM inhibited the osteoclastic differentiation, which responding to receptor activator of NF-κB ligand (RANKL) and a tumor necrosis factor a (TNF-α). Ganoderic acid DM showed the dual functions such as anti-androgenic and anti-osteoclastic differentiation activities, which can be used to explain the multifunction of G. lucidum. The accumulation of the knowledge of biological activities of these kinds of triterpenoids leads us to give some hints in elucidating the unsolved function of G lucidum.
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[Journal Article] The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum2009
Author(s)
S. Fatmawatia, K. Kurashiki, S. Takeno, Y. Kim, K. Shimizu, M. Sato, K. Imaizumi, K. Takahashi, S. Kamiya, S. Kaneko, R. Kondo
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Journal Title
Phytother. Res. 23
Pages: 28-32
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[Journal Article] An extract of Ganoderma lucidum in men with lower urinary tract symptoms: A double-blind, placebo-controlled randomized and dose-ranging study2008
Author(s)
M. Noguchi, K. Tomiyasu, M, Nakiri, K. Matsuoka, T. Kakuma, F. Konishi, S. Kumamoto, K. Shimizu, R. Kondo
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Journal Title
Nishinihon Journal of Urology 70(9)
Pages: 466-472
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