2009 Fiscal Year Final Research Report
A new role of Prostaglandin D2 in vascular homeostasis
| Project/Area Number |
19688014
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MURATA Takahisa The University of Tokyo, 大学院・農学生命科学研究科, 助教 (40422365)
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| Project Period (FY) |
2007 – 2009
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| Keywords | プロスタグランジン / 血管 / 血管透過性 / 腫瘍 |
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| Research Abstract |
In this project, we attempted to elucidate the effects of prostaglandin D_2 (PGD_2) which is well-known as a sleep promoter on vascular function. We found that (1) PGD_2 strongly inhibits vascular permeability through its distinct receptor DP, (2) DP agonism represents strong inhibition on tumor vascular permeability, angiogenesis, and growth, (3) While PGD_2 decreases blood pressure through DP activation, excessive amount of PGD_2 can stimulate other PG receptor TP and then increases blood pressure. We published these results in 12 scientific journals and presented in 15 research conferences.
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