2009 Fiscal Year Final Research Report
Development of highly atom-economical synthetic methods based on catalytic cascade reactions
| Project/Area Number |
19689001
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
OHNO Hiroaki Kyoto University, 薬学研究科, 准教授 (30322192)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 有機化学 |
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| Research Abstract |
The author investigated development of synthetic methods based on catalytic cascade of atom-economical reactions such as C-H bond activation and multi-component reactions. Consequently, several methods for construction of fused heterocycles such as indoles, isoquinolines, isoindoles, carbazoles, and quinazolines have been developed. Furthermore, total syntheses of ergot alkaloids and jaspine B, as well as efficient synthesis of trifluoromethylalkene dipeptide isosteres have been achieved. These results provide a preliminary model for efficient organic synthesis.
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