2010 Fiscal Year Final Research Report
Development of efficient gene transfection system by the combination use of dendritic cells-selective nanoparticle and physical stimulation for cancer therapy
| Project/Area Number |
19689005
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
KAWAKAMI Shigeru Kyoto University, 薬学研究科, 講師 (20322307)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 医療・福祉 / 免疫学 / 癌 / 遺伝子 / ドラッグデリバリー / 遺伝子治療 |
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| Research Abstract |
In this study, we developed mannosylated bubble lipoplex for ultrasound-responsive and cell-selective gene transfer. After administration of mannosylated bubble lipoplex, plasmid DNA was efficiently transfected to the mannose receptors-expressing cells, including dendritic cells and liver non-parenchymal cells followed by ultrasound exposure. Enhanced DNA vaccine potency was also observed by this transfection method.
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