2009 Fiscal Year Final Research Report
Systematic analysis of crosstalk between arrhythmic triggers using functional and mathematical approaches.
| Project/Area Number |
19689006
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KUROKAWA Jyunko Tokyo Medical and Dental University, 難治疾患研究所, 准教授 (40396982)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 不整脈 / 性ホルモン / イオンチャネル / シミュレーション / 交感神経 / 非ゲノム作用 / 薬物性QT延長 / 一酸化窒素 |
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| Research Abstract |
To understand the underlying mechanisms of sex-difference in susceptibility ofarrhythmias induced by long QT intervals, there systemic factors for triggers ofarrhythmias (sex hormones, sympathetic nervous system stimulation, and drugs) wereanalyzed. We then found an involvement of non-genomic action of sex-hormones in the sexdifference, a novel mechanism for regulation of a K+ channel by nitric oxide, and effectsof estrogen on sensitivity of QT-prolonging drugs. These data were introduced into acomputer simulation model of cardiac action potentials. The model could assess the sexdifference of susceptibility of arrhythmias induced by QT-prolonging drugs.
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[Presentation]2007
Author(s)
古川哲史, 黒川洵子, 中村浩章, 白長喜, 浅田健, 玉川正次、中谷晴昭、Ronit Vatkin, Jun Xu, Colleen E. Clancy, 磯部光章
Organizer
第24回日本心電学会学術集会学術諮問委員会指定シンポジウム
Place of Presentation
名古屋
Year and Date
20071005-20071006
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