2009 Fiscal Year Final Research Report
Generation and application of the novel mouse model for Alzheimer's disease
| Project/Area Number |
19689009
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SAITO Takashi The Institute of Physical and Chemical Research, 神経蛋白制御研究チーム, 研究員 (90360552)
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| Project Period (FY) |
2007 – 2009
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| Keywords | アルツハイマー病 / モデルマウス / アミロイド前駆体蛋白 / アミロイドβペプチド / プレセニリン1 |
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| Research Abstract |
We generated two lines of the novel mouse model for Alzheimer's disease (AD), amyloid precursor protein (APP) knock-in (KI) mouse and presenilin1(PS1)-KI mouse. Each KI mice has the familial AD mutations. The mice showed relevance phenotypes rather than previous AD model mouse. These mice would be a useful tool for the prevention, the treatment and the drug discovery of AD.
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