2010 Fiscal Year Final Research Report
Development of a new therapeutid agent for internal radiation therapy and monitoring using Auger electron emitting radionuclides
| Project/Area Number |
19689026
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
KIYONO Yasushi University of Fukui, 高エネルギー医学研究センター, 准教授 (50305603)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 放射線治療学 / 内用放射線治療 / オージェ電子 |
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| Research Abstract |
The production of Br-77 was achived using small medical cycltoron. The thymidine derivative radiolabeled with Br-77 was designed and synthesized for internal radiation therapy using Auger electron. This compoound was incorporated into DNA fraction. After incorporation, the effect of internal radiation with Auger electron was appeared as the supression of cell proliferation. This cell proliferation was induced by the appoptosis in damage cells. Gathering these findings, the internal radiation therapy using Br-77 would be a new promissing therapy for cancer treatment.
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