2009 Fiscal Year Final Research Report
Remedy for spinal cord injury focused on stem cells and self-repairing
| Project/Area Number |
19689031
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
OKADA Seiji Kyushu University, 医学研究院, その他 (30448435)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 脳脊髄 / 脊髄損傷 / 再生医療 |
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| Research Abstract |
Although reactive astrocytes form a glial scar and are considered a physical barrier to prevent axonal regeneration, we found that reactive astrocytes play a crucial role in wound healing and functional recovery after spinal cord injury. To examine their cellular property, we utilized cell sorter and isolated them from injured spinal cord. We confirmed their property as neural stem/progenitors in vitro but no neuronal contribution in vivo. The method of flow cytometric sorting for neural cells could be a powerful tool for neuroscience research.
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[Journal Article] Does ossification of the posterior longitudinal ligament affect the neurological outcome following traumatic cervical cord injury?2009
Author(s)
Okada S, Maeda T, Ohkawa Y, Harimaya K, Saiwai H, Kumamaru H, Matsumoto Y, Doi T, Ueta T, Shiba K, Iwamoto Y
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Journal Title
Peer Reviewed
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[Journal Article] Roles of ES cell-derived gliogenic neural stem /progenitor cells in functional recovery after spinal cord injury.2009
Author(s)
Kumagai G, Okada Y, Yamane J, Nagoshi N, Kitamura K, Mukaino M, Tsuji O, Fujiyoshi K, Okada S, Shibata S, Matsuzaki Y, Toh S, Toyama Y, Nakamura M, Okano H
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Journal Title
Plos One 4(11)
Pages: 7706
Peer Reviewed
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[Journal Article] Ontogeny and Multipotency of neural crest-derived stem cells in bone marrow, dorsal root ganglia and whisker pad of adult rodents.2008
Author(s)
Nagoshi N, Shibata S, Kubota Y, Nakamura M, Nagai Y, Satoh E, Morikawa S, Okada Y, Mabuchi Y, Katoh H, Okada S, Fukuda K, Suda T, Matsuzaki Y, Toyama Y, Okano H
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Journal Title
Cell Stem Cell. 2
Pages: 392-403
Peer Reviewed
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[Journal Article] Diffusion tensor tractography of injured spinal cord in non-human primates.2007
Author(s)
Fujiyoshi K, Yamada M, Nakamura M, Yamane J, Kato H, Kitamura K, Kawai K, Okada S, Momoshima S, Toayama Y, Okano H
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Journal Title
J Neurosci. 27
Pages: 11991-8
Peer Reviewed
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[Journal Article] Electrical stimulation modulates fate determination of differentiating embryonic stem cells2007
Author(s)
Yamada M, Tanemura K, Okada S, Iwanami A, Nakamura M, Mizuno H, Ozawa M, Ohyama R, Kitamura N, Kawano M, Takeuchi K, Ishitsuka C, Nagai A, Miyawaki A, Takashima A, Ogawa M, Toyama Y, Okano H, Kondo T
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Journal Title
Peer Reviewed
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