2009 Fiscal Year Final Research Report
Regulation of bone remodeling
| Project/Area Number |
19689036
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NAKASHIMA Tomoki Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (00346959)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 口腔生化学 / 骨代謝学 |
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| Research Abstract |
Bone remodeling optimizes bone strength and mineral metabolism. Control of bone remodeling requires a tightly orchestrated interplay among osteoblasts (bone forming cells), osteoclasts (bone resorbing cells) in bone surface and osteocytes, which embedded into bone. To identify the regulation factor of bone remodeling, we performed a genome-wide screening of these bone cells and in vivo analysis of gene targeting mice.
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[Journal Article] Roles of IL-6 and PTHrP in osteoclast formation associated with oral cancers : The significance of IL-6 synthesized by stromal cells in response to cancer cells2010
Author(s)
Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Nguyen ST, Omura K, Miki Y, Akashi T, Ogata E, Yamaguchi A
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Journal Title
Am J Pathol 176
Pages: 968-980
Peer Reviewed
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[Journal Article] Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.2007
Author(s)
Pospisilik JA, Knauf C, Joza N, Benit P, Orthofer M, Cani PD, Ebersberger I, Nakashima T, Sarao R, Neely G, Esterbauer H, Kozlov A, Kroemer G, Kahn CR, Rustin P, Burcelin R, Penninger JM
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Journal Title
Peer Reviewed
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