2009 Fiscal Year Final Research Report
Transcruptional Regulation of Sox9 during endochondral ossification
| Project/Area Number |
19689037
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
HATA Kenji Osaka University, 大学院・歯学研究科, 助教 (80444496)
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| Co-Investigator(Renkei-kenkyūsha) |
YONEDA Toshiyuki 大阪大学, 大学院・歯学研究科, 教授 (80142313)
NISHIMURA Riko 大阪大学, 大学院・歯学研究科, 准教授 (60294112)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 口腔生化学 / 軟骨細胞 / 転写因子 / Sox9 |
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| Research Abstract |
Most of bones were formed through unique ossification pathway called endochondral ossification. It is well known that transcriptional factor Sox9 is essential for chondrocyte differentiation. To understand the molecular basis for chondrogenesis, we established screening system which can allow us to identify transcriptional co-factor for Sox9. We have identified p54^<nrb> and Dmrt5 as a novel transcriptional partner for Sox9. Further studies revealed that p54^<nrb> modulate mRNA splicing of Sox9 target genes. Moreover, we found that Dmrt5 is involeved in Sox9 dependent sex differentiation as well as chondrocyte differentiation. Our findings indicate that the screening system is valid and the newly identified Sox9 transcriptional cofactor is important for chondrocyte differentiation.
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[Journal Article] Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function.2007
Author(s)
Shimoyama A, Wada M, Ikeda F, Hata K, Matsubara T, Nifuji A, Noda M, Amano K, Yamaguchi A, Nishimura R, Yoneda T
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Journal Title
Mol Biol Cell 18
Pages: 2411-2418
Peer Reviewed
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