Robust inference and its application to genome data

2009 Fiscal Year Final Research Report

• Project/Area Number: 19700270
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Statistical science
• Research Institution: The Institute of Statistical Mathematics
• Principal Investigator: FUJISAWA Hironori The Institute of Statistical Mathematics, 数理・推論研究系, 准教授 (00301177)
• Project Period (FY): 2007 – 2009
• Keywords: ロバスト推測 / 遺伝子発現データ / 一塩基多型

Research Abstract

When outliers are present, many statistical methods lose the validity of the result for analyzing the data. The statistical method which gives the valid result even if outliers are present is called the robust inference. In particular, it is important to make a latent bias small even when outliers are present. I have discussed robust inference and applied the method to genome data.

Research Products

• [Journal Article] SNEP: Simultaneous detection of nucleotide and expression polymorphisms using Affymetrix GeneChip. (2009)
  • Author(s): Fujisawa, H., Horiuchi, Y., Harushima, Y., Takada, T., Eguchi, S., Mochizuki, T., Sakaguchi, T., Shiroishi, T., Kurata, N.
  • Journal Title: BMC Bioinformatics Vol.10,No.131
  • Peer Reviewed
• [Journal Article] Robust parameter estimation with a small bias against heavy contamination. (2008)
  • Author(s): Fujisawa, H., Eguchi, S.
  • Journal Title: Journal of Multivariate Analysis Vol.99 Pages: 2053-2081
  • Peer Reviewed
• [Journal Article] Identifying haplotype block structure by using ancestor-derived model. (2007)
  • Author(s): Fujisawa, H., Isomura, M., Eguchi, S., Ushijima, M., Miyata, S., Miki, Y., Matsuura, M.
  • Journal Title: Journal of Human Genetics Vol.52 Pages: 738-746
  • Peer Reviewed
• [Journal Article] A conservative test for multiple comparison based on highly correlated test statistics. (2007)
  • Author(s): Ninomiya, Y., Fujisawa, H.
  • Journal Title: Biometrics Vol.63 Pages: 1135-1142
  • Peer Reviewed
• [Presentation] Affymetrix GeneChipを利用した塩基多型と発現多型の同時同定 (2010)
  • Author(s): 藤澤洋徳
  • Organizer: 統計的推測法の発展と応用
  • Place of Presentation: 広島
  • Year and Date: 2010-03-17
• [Presentation] SNEP: Simultaneous detection of nucleotide and expression polymorphisms using Affymetrix GeneChip (2010)
  • Author(s): 藤澤洋徳
  • Organizer: 統計科学セミナー
  • Place of Presentation: 福岡
  • Year and Date: 2010-01-08
• [Presentation] Statistical Analysis of Affymetrix GeneChip Data (2009)
  • Author(s): Fujisawa, Hironori
  • Organizer: 2nd joint research meeting of ISI, ISM and ISSAS
  • Place of Presentation: Mishima, Japan
  • Year and Date: 2009-10-12
• [Presentation] A simple selection of smoothing parameter in penalized spline regression (2009)
  • Author(s): Fujisawa, Hironori
  • Organizer: Joint Statistical Meting 2009
  • Place of Presentation: Washington, D.C., USA
  • Year and Date: 2009-08-04
• [Presentation] Multiplicity adjustments in detecting reproductive barriers caused by Loci interactions (2009)
  • Author(s): Kuriki, Satoshi
  • Organizer: BIRS Workshop 09w5040 Random Fields and Stochastic Geometry
  • Place of Presentation: Banff, Canada
  • Year and Date: 2009-02-26
• [Presentation] Robust parameter estimation with a small bias against heavy contamination (2009)
  • Author(s): Fujisawa, Hironori
  • Organizer: Statistical Science's colloquium series at Cornell University
  • Place of Presentation: New York, USA
  • Year and Date: 2009-02-25
• [Presentation] 罰則付スプライン回帰におけるスムージングパラメータの簡単な選択法 (2008)
  • Author(s): 藤澤洋徳
  • Organizer: 統計関連学会連合大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-09-08
• [Presentation] A sequential selection of smoothing parameter in penalized spline regression (2008)
  • Author(s): Fujisawa, Hironori
  • Organizer: 2008 Joint Meeting of ISI, ISM and ISSAS
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2008-06-19
• [Presentation] SNPを考慮に入れた遺伝子発現データ解析 (2008)
  • Author(s): 藤澤洋徳
  • Organizer: シンポジウム「バイオインフォマティックスおよび経時観察データの解析」
  • Place of Presentation: 廿日市
  • Year and Date: 2008-02-08
• [Presentation] A unified method for detecting single feature polymorphisms and gene expression level differences (2008)
  • Author(s): Fujisawa, Hironori
  • Organizer: Pasific Symposium on Biocomputing
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2008-01-06
• [Presentation] A unified method for detecting single feature polymorphisms and gene expression level differences (2007)
  • Author(s): Fujisawa, Hironori
  • Organizer: 1st joint research meeting of ISM and ISSAS (on Bioinfomatics)
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2007-11-30
• [Presentation] 異分野コミュニケーション～円滑にするコツは?～ (2007)
  • Author(s): 藤澤洋徳
  • Organizer: 情報・システム研究機構若手クロストーク研究会
  • Place of Presentation: 三島
  • Year and Date: 2007-11-26
• [Presentation] 遺伝子座間の相互作用による生殖的隔離障壁の検出と多重性調整 (2007)
  • Author(s): 栗木哲
  • Organizer: 統計関連学会連合大会
  • Place of Presentation: 神戸
  • Year and Date: 2007-09-07
• [Presentation] SNPを考慮した遺伝子発現データ解析 (2007)
  • Author(s): 藤澤洋徳
  • Organizer: 統計関連学会連合大会
  • Place of Presentation: 神戸
  • Year and Date: 2007-09-07
• [Presentation] 数理統計学とデータ解析, 統計数理研究所 (2007)
  • Author(s): 藤澤洋徳
  • Organizer: 統計数理研究所外部評価シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-08-13
• [Presentation] SNPを考慮した遺伝子発現データ解析 (2007)
  • Author(s): 藤澤洋徳
  • Organizer: 統計若手サマーセミナー
  • Place of Presentation: 指宿
  • Year and Date: 2007-08-07
• [Remarks] Fujisawa et al. (2009, BMC Bioinformatics)で開発したソフトウェア「SNEP」のホームページ
  • URL: http://www.ism.ac.jp/~fujisawa/SNEP/