2009 Fiscal Year Final Research Report
Theoretical study on the regeneration of neuronal circuits during rehabilitation
| Project/Area Number |
19700281
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Yamagata University |
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Principal Investigator |
KUBOTA Shigeru Yamagata University, 大学院・医学系研究科, 准教授 (60396588)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 可塑性 / シナプス競合 / NMDA受容体 / GABA / STDP |
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| Research Abstract |
For the improvement of the outcome of rehabilitation after nerve injury, it is important to understand the mechanism underlying the organization of synaptic circuits. Therefore, this study has analyzed by developing a cortical pyramidal neuron model the influences of NMDA receptor (NMDAR) subunit expression and GABA inhibition, which are modulated through the nerve injury, on the organization process. The results have shown that the coordinated action of the NMDAR and GABA functions can regulate the fundamental properties of organization such as the balance between long-term potentiation and depression, the Hebbian effects, and the synaptic competition.
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