2009 Fiscal Year Final Research Report
A study for axon regeneration in the damaged CNS -clarification of inhibitory mechanisms of chondroitin sulfate proteoglycan
| Project/Area Number |
19700301
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KUBOYAMA Tomoharu The Institute of Physical and Chemical Research, 神経成長機構研究チーム, 研究員 (10415151)
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| Project Period (FY) |
2007 – 2009
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| Keywords | コンドロイチン硫酸プロテオグリカン / プロテインキナーゼA / 細胞接着斑 / パキシリン / 軸索再生 |
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| Research Abstract |
I attempt to molecularly clarify why axons cannot regenerate in the damaged spinal cord where a gradient of chondroitin sulfate proteoglycan (CSPG) is formed. I used a culture system that reproduced axon endings failing to migrate forward on the inhibitory CSPG gradient. In this study, I conclude that regulation of cell-matrix adhesion formation plays a critical role in axon regeneration across the inhibitory CSPG gradient.
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