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2008 Fiscal Year Final Research Report

Functional roles of different types of inhibitory interneurons in the short-term memory-associated cortical persistent activity

Research Project

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Project/Area Number 19700310
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

MORITA Kenji  The Institute of Physical and Chemical Research, 甘利研究ユニット, 基礎科学特別研究員 (60446531)

Project Period (FY) 2007 – 2008
Keywords大脳皮質 / 短期記憶 / 持続的活動 / 抑制性神経細胞 / 樹状突起 / 数理モデル
Research Abstract

短期記憶・作業記憶の神経基盤と考えられる大脳皮質の持続的神経活動の神経回路メカニズム、特に抑制性細胞の多様性や樹状突起の空間的非一様性等の効果を数理モデルを用いて研究した。そして、興奮性錐体細胞の樹状突起分枝に投射する抑制性細胞の作用、及びそれに伴う樹状突起分枝上の非線形な入力加算が、記憶対象と関係の無い非特異的な入力を受けた場合に不適切な応答が起こらないことを保証する働きをしている可能性などを示した。

  • Research Products

    (6 results)

All 2009 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Computational implications of cooperative plasticity induction at nearby dendritic sites2009

    • Author(s)
      森田賢治
    • Journal Title

      Science Signaling 2(52)

      Pages: 2

    • Peer Reviewed
  • [Journal Article] Possible role of dendritic compartmentalization in the spatial working memory circuit2008

    • Author(s)
      森田賢治
    • Journal Title

      The Journal of Neuroscience 28(30)

      Pages: 7699-7724

    • Peer Reviewed
  • [Presentation] Effects of dendritic compartmentalization on the property of spatial working memory2008

    • Author(s)
      森田賢治
    • Organizer
      Computational and Systems Neuroscience 2008 (Cosyne)
    • Place of Presentation
      Salt Lake City, Utah, USA
    • Year and Date
      2008-03-01
  • [Presentation] A field equation model of the neuronal network dynamics incorporating two stages of nonlinear input integrations in individual neurons2007

    • Author(s)
      森田賢治, 甘利俊一
    • Organizer
      Society for Neuroscience (Annual Meeting 2007)
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2007-11-06
  • [Presentation] 単一神経細胞の樹状突起の有する潜在的計算能力は、高次機能にどのように関わり得るか : 短期記憶のネットワークモデルを例とした理論的検討2007

    • Author(s)
      森田賢治, 岡田真人, 合原一幸
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-10
  • [Book] Progress in Neurocomputing Research2008

    • Author(s)
      森田賢治
    • Total Pages
      115-140
    • Publisher
      Nova Science Publishers

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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