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2008 Fiscal Year Final Research Report

Guidance mechanism of main and accessory olfactory bulb axons

Research Project

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Project/Area Number 19700325
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nerve anatomy/Neuropathology
Research InstitutionNational Institute of Genetics

Principal Investigator

KAWASAKI Takahiko  National Institute of Genetics, 総合遺伝研究系, 助教 (00322751)

Project Period (FY) 2007 – 2008
Keywords神経回路網
Research Abstract

本研究では主嗅球と副嗅球という嗅球の違いに注目しながら、嗅球から終脳中枢への軸索投射が胚発生期にどのように制御されているのかを明らかにしようと解析を進めた。in vitroやin vivoの解析によって、主嗅球の軸索投射は主にSlit/Roboシグナリングが制御し、副嗅球の軸索投射は主にNrp2を介したSerna3/Nrp/Plnシグナリングが制御していることを明らかにした。

  • Research Products

    (6 results)

All 2009 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface2008

    • Author(s)
      Keisuke Ito, Takahiko Kawasaki, Seiji Takashima, Ikuo Matsuda, Atsu Aiba, and Tatsumi Hirata
    • Journal Title

      J. Neurosci. vol.28

      Pages: 4414-4422

    • Peer Reviewed
  • [Journal Article] Robo1 and Robo2 control the development of the lateral olfactory tract2007

    • Author(s)
      Coralie Fouquet, Thomas Di Meglio, LeMa, Takahiko Kawasaki, Hua Long, Tatsumi Hirata, Marc Tessier-Lavigne, Alain Che'dotal, and Kim T. Nguyen-Ba-Charvet
    • Journal Title

      J. Neurosci. vol.27

      Pages: 3037-3045

    • Peer Reviewed
  • [Presentation] Novel function of Nrp2 as an inhibitor of Sema3A signaling in the projection of olfactory bulb axons2009

    • Author(s)
      Takahiko Kawasaki and Tatsumi Hirata
    • Organizer
      The 32st Annual meeting of the Japan neuroscience society
    • Place of Presentation
      新潟
    • Year and Date
      20090500
  • [Presentation] The role of semaphorin signaling in the olfactory bulb projections2008

    • Author(s)
      Takahiko Kawasaki and Tatsumi Hirata
    • Organizer
      The 31st Annual meeting of the Japan neuroscience society
    • Place of Presentation
      東京
    • Year and Date
      20080700
  • [Presentation] The role of semaphorin signaling in the projections of olfactory bulb axons2008

    • Author(s)
      Takahiko Kawasaki and Tatsumi Hirata
    • Organizer
      41st Annual meeting for the Japanese society of developmental biology
    • Place of Presentation
      徳島
    • Year and Date
      20080500
  • [Presentation] Guidance of main and accessory olfactory bulb axons2007

    • Author(s)
      Takahiko Kawasaki and Tatsumi Hirata
    • Organizer
      40st Annual meeting for the Japanese society of developmental biology
    • Place of Presentation
      福岡
    • Year and Date
      20070500

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Published: 2010-06-10   Modified: 2016-04-21  

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