2011 Fiscal Year Final Research Report
Mechanisms of the extrapyramidal symptoms caused by methylmercury chloride
| Project/Area Number |
19700334
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | National Institute for Minamata Disease |
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Principal Investigator |
MARUMOTO Masumi 国立水俣病総合研究センター, 基礎研究部, 主任研究員 (00335506)
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| Project Period (FY) |
2007 – 2011
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| Keywords | メチル水銀 / 水俣病 / マウス / 線条体 / 小型神経細胞 / 錐体外路 |
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| Research Abstract |
The patients who had severe symptom of Minamata disease and, in the case that an extrapyramidal sign was observed clinically, showed pathological changes in the extrapyramidal tract nuclei. In addition, pathological changes were observed in the extrapyramidal tract nuclei in the case that whole brain was damaged severely. The methylmercury treated mice displayed locomotor hyperactivity. Histopathological examination showed significant decrease in the number of neurons with proliferation of astroglias in the bilateral caudate putamen in the methylmercury treated mice.
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