2010 Fiscal Year Final Research Report
Molecular analysis of ephrin-Eph associated signaling pathways in the neural stem cell proliferation and differentiation
| Project/Area Number |
19700346
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
SAWADA Takahiro Wakayama Medical University, 先端医学研究所, 助教 (00382325)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 細胞内情報伝達 / 神経幹細胞 |
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| Research Abstract |
We demonstrated previously that FGFRs and EphA4 trans-activate each other by forming a heterodimer, and augment downstream signals through FRS2α, a major docking protein of FGFRs, and MAP kinase. Based on these studies, I have studied the interaction domains among EphA4, FGFRs and FRS2α, and trans-phosphorylation partners of the two receptor tyrosine kinases. EphA4 interacts directly with and phosphorylates not only FGFRs but also FRS2α. From these interaction studies, it has become clear that EphA4, FGFR and FRS2α compose a ternary complex, which plays an important role in proliferation and differentiation of neural stem cells. Furthermore, I also found that FGFR directly activates ephexin1, a downstream molecule of EphA4, which regulates migration and morphological changes of neuronal cells through activation of Rho family. These studies show that the interaction of EphA4 with FGFR functions as a molecular mediator for neural cell proliferation, migration and differentiation.
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[Journal Article] Involvement of GCMB in the transcriptional regulation of the human parathyroid hormone gene in a parathyroid-derived cell line PT-r : Effects of calcium and 12010
Author(s)
Masayuki, Kawahara, Yasumasa Iwasaki, Kazushige Sakaguchi, Takafumi Taguchi, Mitsuru Nishiyama, Takeshi Nigawara, Machiko Kambayashi, Takahiro Sawada, Xuefeng Jing, Masayasu Miyajima, Yoshio Terada, Kozo Hashimoto, Toshihoro Suda.
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Journal Title
25(OH)_2D_3. Bone 47
Pages: 534-541
Peer Reviewed
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