2009 Fiscal Year Final Research Report
Modulatory effects of oligodendrocytes on axonal conduction of action potentials
| Project/Area Number |
19700356
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Yamagata University |
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Principal Investigator |
YAMAZAKI Yoshihiko Yamagata University, 医学部, 准教授 (10361247)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 海馬 / 白板 / オリゴデンドロサイト / 活動電位 / グルタミン酸受容体 / 伝導速度 / 髄鞘 / ラット |
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| Research Abstract |
Oligodendrocytes in the alveus of hippocampus were found to respond to exogenously applied glutamate receptors with depolarization. Electrical stimulation evoked inward currents through various routes involving glutamate receptors and inward rectifier potassium channels. Direct depolarization of oligodendrocytes shortened the latencies of action potentials, indicating that oligodendrocytes increase the conduction velocity of action potentials by another mechanism in addition to saltatory conduction and play active roles in information processing in the brain.
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