2010 Fiscal Year Final Research Report
Prolonged effect of carnitine administration : Changes of energy production in carnitine-deficient mice
| Project/Area Number |
19700523
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | National Institute of Fitness and Sports in Kanoya |
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Principal Investigator |
YOSHIDA Goichiro National Institute of Fitness and Sports in Kanoya, 体育学部, 准教授 (10274870)
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| Project Period (FY) |
2007 – 2010
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| Keywords | エネルギー産生 / カルニチン / 脂肪酸代謝 / JVSマウス / 絶食 |
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| Research Abstract |
In this study, I examined the prolonged effects of single carnitine administration on the energy expenditure of fasted carnitine-deficient juvenile visceral steatosis (jvs^<-/->) mice. The study was able to evaluate the in vivo long-chain fatty acid (LCFA) oxidation activity of the mice under various conditions by intravenously injecting [1-^<14>C]-palmitic acid and measuring the breath or expiratory ^<14>C-CO_2. Leptin, which stimulates the AMP-activated protein kinase (AMPK), increased in the plasma after a single carnitine administration in jvs^<-/-> mice.
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[Journal Article] Failure of the feeding response to fasting in carnitine- deficient juvenile visceral steatosis (JVS) mice : involvement of defective acyl-ghrelin secretion and enhanced corticotropin- releasing factor signaling in the hypothalamus.2009
Author(s)
Takeo Sakoguchi, Masahisa Horiuchi, Aki- hiro Asakawa, Miharu Ushikai, Goichiro Yoshida, Mineko Fujimiya, Ikuko Kato, Masamitsu Nakazato, Toru Takeuchi, Takeyori Saheki, Akio Inui.
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Journal Title
Biochim Biophys Acta 1792(11)
Pages: 1087-1093
Peer Reviewed
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