2009 Fiscal Year Final Research Report
Study of the mechanisms on anti-allergy factors targeting leukotrienes in food.
| Project/Area Number |
19700596
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyushu Sangyo University |
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Principal Investigator |
TAKASUGI Mikako Kyushu Sangyo University, 工学部, 講師 (60305802)
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| Project Period (FY) |
2007 – 2009
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| Keywords | アレルギー・ぜんそく / 食品 / ロイコトリエン |
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| Research Abstract |
We developed the method to analyze regulatory factors of leukotriene release in a mouse mast cell line. The method was applied to investigate effect of soy isoflavones on leukotriene release from mast cells. It was elucidated that daizein and genistein, soy isoflavone agrycones and equol, a metabolite of soy isoflavone, supressed leukotrine B4 in dose-dependent manner. Equol also suppressed Ca^<2+> influx into mast cells, although genistein exerted no effect.
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