2009 Fiscal Year Final Research Report
Cellular senescence mechanisms and cellular antioxidant systems by lipid hydroperoxides
| Project/Area Number |
19700605
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
YAMANAKA Yukako Mukogawa Women's University, 生活環境学部, 助手 (80434934)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 食と栄養 / 細胞老化 |
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| Research Abstract |
The aged society has come in the world including Japan. Then senile dementia lies as the problem to be conquest. The purpose of this investigation is to make clarify the aging mechanism of living cells and the results obtained would give the solution against a senile dementia. The effect of lipid hydroperoxides on PC12 cells, which is a model of nerve cells, was examined. Lipid hydroperoxides injured cell membrane and the cell functions were lost. Especially it was shown that lipid hydroperoxides damaged to the function of microtubules. Moreover, it was found that lipid hydroperoxides raised some enzyme activities of antioxidation system.
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