Effect of dietary education utilizing genetic diagnosis using DNA from nail clippings

2009 Fiscal Year Final Research Report

• Project/Area Number: 19700606
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Mukogawa Women's University Junior College Division
• Principal Investigator: YAMAMOTO Shuumi (吉田 周美) Mukogawa Women's University Junior College Division, 短期大学部・食生活学科, 講師 (60441234)
• Project Period (FY): 2007 – 2009
• Keywords: 食育 / 遺伝子診断 / 遺伝子多型 / 最大骨量 / 骨粗鬆症 / 予防栄養 / 若年女性

Research Abstract

The purpose of this study is to clarify the effect of dietary education utilizing genetic diagnosis using DNA from nail clippings. Since we focused on the dietary education to increase the bone mass, we also tried to clarify the genetic and environmental factor that influences the peak bone mass. As a result, we find out that LRP5 (rs376228) is one of the polymorphisms that affects peak bone mass and exercise experience increases the bone mass. Given that the genetic diagnosis using DNA from nail clipping have a non-invasive benefit and raise the young people's awareness of their own health, it could be a useful tool for dietary education.

Research Products

• [Journal Article] Efficient DNA Extraction from Nail Clippings Using the Protease Solution from Cucumis melo (2010)
  • Author(s): Yoshida-Yamamoto S, et al.
  • Journal Title: Molecular Biotechnology Epubaheadofprint
  • Peer Reviewed
• [Journal Article] An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta 1, 4-N-acetylglucosaminyltransferase III (2009)
  • Author(s): Sato Y, et al.
  • Journal Title: Journal of Biological chemistry 284 Pages: 11873-11881
  • Peer Reviewed
• [Presentation] 母体・胎児のトランス脂肪酸解析 (2010)
  • Author(s): 山本周美
  • Organizer: 日本小児栄養研究会
  • Place of Presentation: 京都大学医学部芝蘭会館
  • Year and Date: 2010-03-06
• [Presentation] メロン由来プロテアーゼを用いる効率的DNA抽出方法の確立 (2009)
  • Author(s): 山本周美
  • Organizer: 第14回日本食品化学学会総会・学術大会
  • Place of Presentation: 武庫川女子大学
  • Year and Date: 2009-05-30
• [Presentation] 爪遺伝子診断による若年女性への食育 (2007)
  • Author(s): 吉田周美
  • Organizer: 日本栄養食糧学会60周年記念シンポジウム
  • Place of Presentation: 京都国際会館
  • Year and Date: 2007-05-19
• [Book] 栄養教育論 (2010)
  • Author(s): 田中敬子, 他
  • Total Pages: 149(37-42、87-91、118-125)
  • Publisher: 朝倉書店
• [Book] 栄養学研究の最前線 (2008)
  • Author(s): 吉田周美, 他
  • Total Pages: 203(191-198)
  • Publisher: 建帛社