Functional analysis and comprehensive isolation of meiosis-specificgenes is Schizosaccharomyces pombe.

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19710164
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 基礎ゲノム科学
• Research Institution: Osaka University
• Principal Investigator: OKUZAKI Daisuke Osaka University, 微生物病研究所, 助教 (00346131)
• Project Period (FY): 2007 – 2010
• Keywords: 分裂酵母 / 減数分裂 / 生殖・分化 / 細胞周期 / リン酸化

Research Abstract

生殖細胞の研究は必須かつ急務だがヒトや高等生物では倫理的・技術的な問題を抱える。この問題を克服するため、生殖・減数分裂の研究に分裂酵母をモデル生物とし十数年前より研究を続けている。"他段階差引法"という独自技術とゲノム情報を基盤とした網羅的解析によって減数分裂特異的に転写誘導される遺伝子群の包括的単離と機能解析を行い、哺乳動物にも存在する遺伝子を多数同定・解析することで哺乳動物の生殖メカニズムへの理解を目指す。

Research Products

• [Journal Article] Mug28, a meiosis-specific protein of Schizosaccharomyces pombe, regulates spore wall formation. (2010)
  • Author(s): Okuzaki D, Shigehisa A, Kasama T, Tohda H, Hi rata A, Nojima H.
  • Journal Title: Molecular Biology of the Cell (in press)
  • Peer Reviewed
• [Journal Article] Mug27/Ppk35 is a meiosis-specific protein kinase that functions in fission yeast meiosis II and sporulation. (2008)
  • Author(s): Ohtaka A, Okuzaki D, Noj ima H
  • Journal Title: J. Cell Sci. vol.121,No.9 Pages: 1547-1558
  • Peer Reviewed
• [Journal Article] Meiosis specific coiled-coil proteins in Shizosaccharomyces pombe. (2007)
  • Author(s): Ohtaka A, Saito TT, Okuzaki D, Noj ima H
  • Journal Title: Cell Div. Vol.2,No.14
  • Peer Reviewed
• [Journal Article] Lats2 is an essential mitotic regulator required for the coordination of cell division. (2007)
  • Author(s): Yabuta N, Okada N, Ito A, Hosomi T, Nishihara S, Sasayama Y, Fuj irnori A, Okuzaki D, Zhao H, Ikawa M, Okabe M, Noj ima H
  • Journal Title: J Biol Chem vol.282,No.26 Pages: 19259-19271
  • Peer Reviewed
• [Journal Article] Mcp4, a meiotic coiled-coil protein, plays a role in F-act in positioning during Schizosaccharomlyces pombe meiosis. (2007)
  • Author(s): Ohtaka A, Okuzaki D, Saito TT, Noj ima H
  • Journal Title: Eukaryot Cell. vol.6,No.6 Pages: 971-983
  • Peer Reviewed
• [Presentation] MUG28, A MEIOSIS-SPECIFIC PROTEIN OF SCHIZOSACCHAROMYCES POMBE, REGULATES SPORE WALL FORMATION (2009)
  • Author(s): 奥崎大介
  • Organizer: The 5th International Fission Yeast Meeting
  • Place of Presentation: 国立オリンピック記念青少年総合センター(東京都)
  • Year and Date: 2009-10-29
• [Presentation] Fission yeast Arp1 facilitates meiotic nuclear oscillation via Dhc1 and Mcp5. (2008)
  • Author(s): 奥崎大介
  • Organizer: The 2008 Yeast Genetics and Molecular Biology Meeting
  • Place of Presentation: カナダ・トロント大学
  • Year and Date: 2008-07-23