2009 Fiscal Year Final Research Report
Total Synthesis and Mechanistic Studies on Cortistatins,Anti-angiogenesis Reagents
| Project/Area Number |
19710175
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku University |
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Principal Investigator |
YAMASHITA Shuji Tohoku University, 大学院・理学研究科, 助教 (50419991)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 天然物有機化学 / 全合成 |
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| Research Abstract |
Cortistatins exhibit extremely strong cytotoxicity against human umbilical vein endothelial cells. Owing to its unique inhibition activity of angiogenesis and unusual steroidal structure, cortistatins have currently become the most challenging targets in the total synthesis. We originally developed the concise and highly stereoselective routes to cortistatin A and J, the most potent congeners.
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