2009 Fiscal Year Final Research Report
Hypothesis of the second critical point of water and protein folding mechanism
| Project/Area Number |
19750010
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical chemistry
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| Research Institution | Fukuoka University |
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Principal Investigator |
YOSHIDA Koji Fukuoka University, 理学部, 助教 (00309890)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 生物物理 / 中性子散乱 / タンパク質 / 水和 |
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| Research Abstract |
Dynamics of hydration water around proteins and confined water in nano-porous materials (silica and dextran gel) was measured with X-ray and neutron scattering experiments. The temperature behaviors in the relaxation time of confined water molecules in the porous silica change from the Ahrrenus type to the non-Ahrrenus one at around 220 K (fragile-strong transition) where the atomic motion of hydrated proteins changes from a harmonic to anharmonic behavior. From these results, the role of water in protein folding was discussed.
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