2009 Fiscal Year Final Research Report
Preparation of environmental materials consisting of salmon milt DNA
| Project/Area Number |
19750187
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Polymer/Textile materials
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| Research Institution | Okayama University of Science |
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Principal Investigator |
YAMADA Masanori Okayama University of Science, 理学部, 准教授 (80443901)
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| Project Period (FY) |
2007 – 2009
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| Keywords | DNA / 環境浄化剤 / 生体高分子 / 内分泌かく乱化学物質 / インターカレーション / 二重らせん / ダイオキシン / 環境調和型材料 |
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| Research Abstract |
Recently, we prepared water-insoluble DNA-films by UV irradiation. These DNA-films bound endocrine disruptors having a planar structure, such as dioxin and PCB derivatives. However, other harmful endocrine disruptors, which lack a planar structure, such as bisphenol A and diethylstilbestrol, did not bind to the water-insoluble DNA-films. Therefore, we prepared the DNA.cyclodextrin composite material by mixing the DNA and the cyclodextrin (CD). As a result, these composite materials had properties of both the double-stranded DNA, such as intercalation, and the CD, such as encapsulation of an organic molecule into the intramolecular cavity. Therefore, these materials could accumulate not only the harmful compounds with a planar structure, but also the non-planar molecules, such as bisphenol A and diethylstilbestrol. These DNA-CD composite materials may have the potential as novel environmental materials that absorb harmful compounds.
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