2008 Fiscal Year Final Research Report
Lifestyle Related Diseases Gene Variants and The Natural History of Mongoloids
| Project/Area Number |
19770214
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anthropology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
NAKAYAMA Kazuhiro Jichi Medical University, 医学部, 助教 (90433581)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 進化人類学 / 人類遺伝学 / 生活習慣病 / 遺伝子多型 / 節約遺伝子 |
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| Research Abstract |
アジア・太平洋地域の人類集団について、糖尿病・肥満・高脂血症・高血圧症などとの関連が指摘されている遺伝子多型の分布および生物学的意義を調査したところ、太平洋地域の人類集団では、インスリン抵抗性や肥満と関連する遺伝子多型が他の人類集団よりも高頻度で見いだされ、また、モンゴル人やチベット人などの中央アジアの人類集団では、遊牧生活に伴う高脂肪食に適応的であると考えられる遺伝子多型の蓄積が確認された。
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[Journal Article] The Jichi Community Genetics Team (JCOG) (2009) Large scale replication analysis of loci associated with lipid concentrations in a Japanese population2009
Author(s)
Nakayama K, Tumenbayar B, Yamanaka K, Kumada M, Gotoh T, Utsumi N, Yanagisawa Y, Okayama M, Kajii E, Ishibashi S, Iwamoto S
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Journal Title
Journal of Medical Genetics published online
Peer Reviewed
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[Journal Article] Diversity in genes responsible for lifestyle-related diseases in Asia-Pacific region.2008
Author(s)
Yanagisawa Y, Munkhtulga L, Nakayama K, Iwamoto S, Charupoonphol P,\ Supannnatas S, Kuartei S, Chimedregzen U, Kawabata T, Kaneko Y, Watanabe S, Sakuma M, Miyagi S, Komatsu F, Hasegawa K, Kagawa Y
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Journal Title
Asia-Pacific Journal of Public Health. 20
Pages: 257-261
Peer Reviewed
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[Journal Article] Polymorphisms of enxyme related to vitamins and tailor-made nutrition2008
Author(s)
Kagawa Y, Higasa S, Tsujimura M, Kageyama M, Yurimoto M, Kontai Y, Kojima S, Ishii Y, Yanagisawa Y, Nakayama K, Iwamoto S, Kagawa Y
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Journal Title
Vitamin 82(3)
Pages: 165-172
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[Journal Article] Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia.2007
Author(s)
Munkhtulga L, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Erdenebulgan B, Zolzaya K, Lkhagvasuren T, Iwamoto S.
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Journal Title
Human Genetics. 120(6)
Pages: 879-888
Peer Reviewed
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