2010 Fiscal Year Final Research Report
Studies on the mechanism of uptake and intracellular dynamics of nicotinic acid and nicotinamide in human cells
| Project/Area Number |
19780095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Mie University |
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Principal Investigator |
OGATA Shin Mie University, 大学院・生物資源学研究科, 助教 (70324556)
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| Project Period (FY) |
2007 – 2010
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| Keywords | ニコチン酸 / ニコチンアミド / NAD / 動物培養細胞 / PARP / Sirtuin |
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| Research Abstract |
Nicotinic acid and nicotinamide are one of water-soluble vitamins and have various physiological functions in mammals. However, the mechanism of uptake and intracellular dynamics of nicotinic acid and nicotinamide are unknown. Especially, it was suggested that nicotinamide and its related compounds were localized in mitochondoria by immunostaing analyses. However, related factors were not identifiable.
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