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2008 Fiscal Year Final Research Report

Involvement of miRNA in mammary gland differentiation

Research Project

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Project/Area Number 19780208
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied animal science
Research InstitutionThe University of Tokyo

Principal Investigator

NAGAOKA Kentaro  The University of Tokyo, 大学院農学生命科学研究科, 助教 (60376564)

Project Period (FY) 2007 – 2008
KeywordsmiRNA / Cox-2 / 乳腺分化 / 細胞増殖
Research Abstract

哺乳動物は妊娠すると、ミルクを作るために乳腺細胞の増殖、分化そして退行を繰り返す。その遺伝子発現は精密に制御されているが、逸脱が生じるとミルク合成量の低下や乳癌の発生などにつながる。本研究により、近年注目を集めているマイクロRNA の一つが、細胞増殖を刺激する遺伝子発現を抑制させ、間接的にマウス乳腺細胞の増殖を制御する事が明らかとなった。今後、より詳細な研究を行うことで、乳腺機構の理解を深めることが可能となろう。

  • Research Products

    (16 results)

All 2009 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (4 results)

  • [Journal Article] Induction of endogenous tau interferon gene transcription by CDX2 and high acetylation in bovine non-trophoblast cells2009

    • Author(s)
      Sakurai T, Sakamoto A, Muroi Y, Bai H, Nagaoka K, Tamura K, Takahashi T, Hashizume K, Sakatani M, Takahashi M, Godkin JD, Imakawa K
    • Journal Title

      Biology of Reproduction 80

      Pages: 1223-1231

    • Peer Reviewed
  • [Journal Article] Interleukin-1 receptor antagonist 1 expression in the equine endometrium during peri-implantation period2009

    • Author(s)
      Haneda S, Nagaoka K, Nambo Y, Kikuchi M, Nakano Y, Matsui M, Miyake Y, Macleod JE, Imakawa K
    • Journal Title

      Domestic Animal Endocrinology 36

      Pages: 209-218

    • Peer Reviewed
  • [Journal Article] MiR-101a controls cell proliferation by regulating cyclooxygenase-2 during mammary gland development2009

    • Author(s)
      Tanaka T, Imakawa K, Sakai S, Nagaoka K
    • Journal Title

      Differentiation 77

      Pages: 181-187

    • Peer Reviewed
  • [Journal Article] Differences in adrenocortical secretory and gene expression responses to stimulation in vitro by ACTH or prolactin between high and low avoidance Hatano rats2009

    • Author(s)
      Jaroenporn S, Nagaoka K, Ohta R, Shirota M, Watanabe G, Taya K
    • Journal Title

      Stress 12

      Pages: 22-29

    • Peer Reviewed
  • [Journal Article] Production of hydrogen peroxide by a small molecular mass compound in milk from Holstein cows with high and low milk somatic cell count.2008

    • Author(s)
      Sakai S, Nonobe E, Satow T, Imakawa K, Nagaoka K
    • Journal Title

      Journal of Dairy Research 75

      Pages: 335-339

    • Peer Reviewed
  • [Journal Article] Generation of hydrogen peroxide by a low molecular weight compound in whey of Holstein dairy cows2008

    • Author(s)
      Sakai S, Satow T, Imakawa K, Nagaoka K
    • Journal Title

      Journal of Dairy Research 75

      Pages: 257-261

    • Peer Reviewed
  • [Journal Article] Comparative effects of prolactin versus ACTH, estradiol, progesterone, testosterone, and dihydrotestosterone on cortisol release and proliferation of the adrenocortical carcinoma cell line H295R2008

    • Author(s)
      Jaroenporn S, Furuta C, Nagaoka K, Watanabe G, Taya K
    • Journal Title

      Endocrine 33

      Pages: 205-209

    • Peer Reviewed
  • [Journal Article] Physiological roles of prolactin in the adrenocortical response to acute restraint stress2007

    • Author(s)
      Jaroenporn S, Nagaoka K, Kasahara C, Ohta R, Watanabe G, Taya K
    • Journal Title

      Endocrine Journal 54

      Pages: 703-711

    • Peer Reviewed
  • [Journal Article] Direct effects of prolactin on adrenal steroid release in male Hatano high-avoidance (HAA) rats may be mediated through Janus kinase 2 (Jak2) activity2007

    • Author(s)
      Jaroenporn S, Nagaoka K, Ohta R, Watanabe G, Taya K
    • Journal Title

      Journal of Reproduction and Development 53

      Pages: 887-893

    • Peer Reviewed
  • [Journal Article] Involvement of RNA binding proteins AUF1 in mammary gland differentiation2007

    • Author(s)
      Nagaoka K, Tanaka T, Imakawa K, Sakai S
    • Journal Title

      Experimental Cell Research 313

      Pages: 2937-2945

    • Peer Reviewed
  • [Journal Article] Prolactin inducesphosphorylation of the STAT5 in adrenal glands of Hatano rats during stress

    • Author(s)
      aroenporn S, Nagaoka K, Ohta R, Watanabe G, Taya K
    • Journal Title

      Life Sci (In press)

    • Peer Reviewed
  • [Journal Article] L-amino acid oxidase plays a crucial role in host defense in the mammary glands

    • Author(s)
      Nagaoka K, Aoki F, Hayashi M, Muroi Y, Sakurai T, Itoh K, Ikawa M, Okabe M, Imakawa K, Sakai S
    • Journal Title

      FASEB Journal (In press)

    • Peer Reviewed
  • [Presentation] ミルク中L-amino acid oxidase (LAO)による乳腺感染防御機構2008

    • Author(s)
      永岡謙太郎、青木不学、伊川正人、岡部勝、今川和彦、酒井仙吉
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      福岡
    • Year and Date
      20080900
  • [Presentation] ミルク中抗菌タンパクLAOノックアウトマウスの解析2008

    • Author(s)
      永岡謙太郎、青木不学、伊川正人、岡部勝、今川和彦、酒井仙吉
    • Organizer
      日本畜産学会第109回大会
    • Place of Presentation
      水戸
    • Year and Date
      20080300
  • [Presentation] 乳腺細胞分化過程におけるRNA 結合タンパクAUF1の関与2007

    • Author(s)
      永岡謙太郎、田中哲也、今川和彦、酒井仙吉
    • Organizer
      第30回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20071200
  • [Presentation] マウス乳腺の退行過程におけるmicroRNA発現変化2007

    • Author(s)
      田中哲也、永岡謙太郎、今川和彦、酒井仙吉
    • Organizer
      日本畜産学会107回大会
    • Place of Presentation
      麻布大学
    • Year and Date
      20070300

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Published: 2010-06-10   Modified: 2016-04-21  

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