2009 Fiscal Year Final Research Report
Synthetic study of acidic inner core oligosaccharides of lipooligo- and lipopolysaccharides produced by gram-negative bacteria
| Project/Area Number |
19780250
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Tottori University |
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Principal Investigator |
イチヤナギ ツヨシ Tottori University, 農学部, 准教授 (00302240)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 糖鎖工学 / リポオリゴ糖 / リポ多糖 / グラム陰性菌 / 2-ケト-3-デオキシマンノオクツロン酸 |
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| Research Abstract |
Design and synthesis of nobel Kdo derivative, methyl 7,8-di-O-benzoyl-4,5-O- isopropylidene-D-manno-octulosonate, for the synthesis of inner-core oligosaccharide of LOS/LPS produced by gram-negative bacteria was successively achieved. It was easily converted to Kdo donor and 4,5-dihydroxyl or 7,8-dihydroxyl Kdo acceptor for the synthesis of Kdo(α2-4)Kdo and Kdo(α2-8)Kdo. Conjugation of Kdo and neutral tetrasaccharide, (Lac(β1-4)[Hep(α1-3)]Hep), with human serum albumin (HSA) was also accomplished.
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