2009 Fiscal Year Final Research Report
Development of functional molecules on the basis of design of novel Lewis acid catalysts
| Project/Area Number |
19790025
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
YANAI Hikaru Tokyo University of Pharmacy and Life Science, 薬学部, 助教 (10408685)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 有機反応学 / 合成化学 / 触媒開発 / ルイス酸 / ブレンステッド酸 / 糖ミメティクス |
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| Research Abstract |
We investigated some synthetic reactions catalyzed Lewis acids. As novel Lewis acidic complexes, aluminum methide and silyl methide were developed. These complexes nicely catalyze the C-C bond forming reactions such as the Diels-Alder reaction and the Mukaiyama-Michael reaction. We also found that chemically stable, mild and soft Lewis acids are effective for the tandem azidation/1,3-dipolar cycloaddition reaction. By using this reaction, 1,2,3-triazole fused carbohydrate mimetics were easily synthesized.
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Research Products
(18 results)
