2010 Fiscal Year Final Research Report
Synthesis of ^<18>F-labeled GABA, amino acids, and lactic acids by using oxazoline precursors
| Project/Area Number |
19790028
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
DOI Hisashi The Institute of Physical and Chemical Research, 分子イメージング標識化学研究チーム, チームリーダー (00421818)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 合成化学 / 生体分子 / 生理活性 / 脳神経 / 放射線 |
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| Research Abstract |
In order to realize synthesis of ^<18>F-labeled GABA, amino acid, and lactic acid, we have investigated ^<18>F-labeling reaction using oxazoline precursors under PET radiolabeling conditions. However, we encountered difficulties to conduct the ^<18>F-labeling under anhydrous conditions by remote-controlling radiolabeling system, and unfortunately, oxazoline precursors underwent radiolysis under the conditions, giving many side products due to decomposition. In the circumstances, we have tried to develop Pd^0-mediated rapid C-[^<18>F]fluoromethylation in parallel and have explored other 18F-labeling methods for the target compounds.
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