2009 Fiscal Year Final Research Report
The function of the homeobox gene Hex in chondrogenesis
| Project/Area Number |
19790073
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
MORIMOTO Riyo Teikyo University, 薬学部, 助教 (00439564)
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| Project Period (FY) |
2007 – 2009
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| Keywords | Hex / 軟骨 / 細胞分化 / ホメオボックス遺伝子 |
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| Research Abstract |
We revealed that the expression and a part of physiological function of Hex in cartilage. Hex mRNA is increased differentiation-dependently in chondrocytes. Hex protein in chondrocyte involved in the nucleocytoplasmic transport. Exogenous Hex induced the cell death in the chondroprogenitor cells. We will elucidate the question whether these cell death is induced during chondrogenesis under physiological conditions.
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