2009 Fiscal Year Final Research Report
Prevention of long term dialysis related complications induced by crosstalk among blood cells
| Project/Area Number |
19790075
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University (2008-2009)
Hoshi University (2007) |
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Principal Investigator |
ITOH Saotmo Nagoya City University, 大学院・薬学研究科, 助教 (70308013)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 細胞生物学 |
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| Research Abstract |
During hemodialysis, the contact of blood components with artificial hemodialysis membranes induce the activation of leukocytes and production of reactive oxygen species (ROS), followed with development of long-term dialysis related complications. In this study, I revealed the mechanism of leukocyte activation induced by hemodialysis membranes, i.e. the contact of blood with hemodialysis membrane evokes expression of P-selectin on activated platelets, formation of platelet-neutrophil microaggregates and production of ROS by neutrophils. The contact of plasma with hemodialysis membrane also activates complement system and induces formation of anaphylatoxin C5a and cap formation of P-selectin ligand on neutrophils which enhances formation of the microaggregates. I found alpha-tocopherol and glycyrrhizin could prevent the interaction of platelets and neutrophils and activation of neutrophils during hemodialysis.
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Research Products
(10 results)
