2009 Fiscal Year Final Research Report
Preparation of lipid nanoparticles modified with cell penetrating peptide for antitumor drug delivery
| Project/Area Number |
19790140
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
KAWANO Kumi Hoshi University, 薬学部, 助教 (20366834)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 抗がん剤 / 脂質微粒子 / リポソーム / 正電荷 / 腫瘍新生血管 / ドラッグデリバリー |
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| Research Abstract |
To improve the chemotherapeutic agents accumulation in tumor tissue, lipid nanoparticles was modified with oligoarginine lipid or cationic lipid. These particles showing cationic charge were accumulated in tumor tissue and tumor vasculature, and enhanced the antitumor activities.
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