Development of metastatic breast cancer therapies with anticancer drug-loaded inorganic nanoparticles targeted to lymph nodes

2009 Fiscal Year Final Research Report

• Project/Area Number: 19790143
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Fujita Health University
• Principal Investigator: MURAKAMI Tatsuya Fujita Health University, 物質-細胞統合システム拠点, 特定拠点助教 (90410737)
• Project Period (FY): 2007 – 2009
• Keywords: ドラッグデリバリー / ナノ粒子 / カーボンナノチューブ / 癌化学療法 / 乳癌 / リンパ節転移 / 腋窩リンパ節 / ドラッグキャリア

Research Abstract

Novel drug-drug carrier complexes with a new type of nanocarbon material, carbon nanohorn (CNH), have been developed. CNH was easily loaded with an anticancer drug, doxorubicin (DXR). The complex slowly released DXR, which would contribute to enhancement of the antitumor activity. When CNH was loaded with an photosensitizer, zinc phthalocyanine (ZnPc), the complex enabled double photodynamic and photothermal cancer therapies. More importantly, CNH administered into tumor-bearing mice was able to accumulate in the adjacent axial lymph nodes, which are well known to be an organ in which breast cancer metastasis often occurs.

Research Products

• [Journal Article] Photoinduced electron transfer in zinc phthalocyanine loaded on single-walled carbon nanohorns in aqueous solution. (2009)
  • Author(s): A.S.D. Sandanayaka, O. Ito, M. Zhang, K. Ajima, S. Iijima, M. Yudasaka, T. Murakami, K. Tsuchida
  • Journal Title: Adv. Mater 21 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Biodistribution and ultrastructural localization of single-walled carbon nanohorns determined in vivo with embedded Gd2O3 labels. (2009)
  • Author(s): J. Miyawaki, S. Matsumura, R. Yuge, T. Murakami, S. Sato, A. Tomida, T. Tsuruo, T. Ichihashi, T. Fujinami, H. Irie, K. Tsuchida, S. Iijima, K. Shiba, M. Yudasaka
  • Journal Title: ACS Nano 3 Pages: 1399-1406
  • Peer Reviewed
• [Journal Article] Fabrication of ZnPc/protein nanohorns for double photodynamic and hyperthermic cancer phototherapy. (2008)
  • Author(s): M. Zhang, T. Murakami, K. Ajima, K. Tsuchida, A.S. Sandanayaka, O. Ito, S. Iijima, M. Yudasaka
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 14773-14778
  • Peer Reviewed
• [Journal Article] Enhancement of in vivo anticancer effects of cisplatin by incorporation inside single-wall carbon nanohorns. (2008)
  • Author(s): K. Ajima, T. Murakami, Y. Mizoguchi, K. Tsuchida, T. Ichihashi, S. Iijima, M. Yudasaka
  • Journal Title: ACS Nano 2 Pages: 2057-2064
  • Peer Reviewed
• [Journal Article] (2008)
  • Author(s): T. Murakami, H. Sawada, G. Tamura, M. Yudasaka, S. Iijima, K. Tsuchida
  • Journal Title: Nanomed 3 Pages: 453-463
  • Peer Reviewed
• [Presentation] ナノ粒子の表面修飾による生体適合化とドラッグデリバリーシステムへの応用 (2009)
  • Author(s): 村上達也
  • Organizer: 日本接着学会東北支部講演会2009
  • Place of Presentation: 東北大学
  • Year and Date: 2009-11-13
• [Presentation] 抗癌活性を有するナノ粒子カーボンナノホーンのin vitroおよびin vivo機能評価 (2007)
  • Author(s): 村上達也
  • Organizer: BMB2007
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2007-12-14
• [Presentation] 局所投与用ドラッグキャリアとしてのカーボンナノホーン (2007)
  • Author(s): 村上達也
  • Organizer: 第29回日本バイオマテリアル学会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
  • Year and Date: 2007-11-26
• [Presentation] 抗癌剤担持水溶性カーボンナノホーンの薬理評価 (2007)
  • Author(s): 村上達也
  • Organizer: 第23回日本DDS学会
  • Place of Presentation: 熊本日航ホテル(熊本)
  • Year and Date: 2007-06-14
• [Remarks]
  • URL: http://www.icems.kyoto-u.ac.jp/j/ppl/grp/murakami.html