2010 Fiscal Year Final Research Report
Calcium coupling between mitochondria and Endoplasmic Reticulum in brown adipocytes
| Project/Area Number |
19790171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Nagoya University of Arts and Sciences |
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Principal Investigator |
HIGURE Yoko Nagoya University of Arts and Sciences, 管理栄養学部, 助教 (30325633)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 褐色脂肪細胞 / ミトコンドリア / 滑面小胞体 / カルシウム |
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| Research Abstract |
In brown adipocytes, activation of β_3-adrenergic causes mitochondria depolarization that causes Ca^<2+> releases from mitochondria, which further elicit CICR from the ER under the actions of locally produced IP_3. The resultant depletion of Ca^<2+> in the ER activates store-operated Ca^<2+> entry.
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Research Products
(5 results)
