2009 Fiscal Year Final Research Report
Control of alternative splicing of insulin receptor by glucocorticoid hormone
| Project/Area Number |
19790218
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Jichi Medical University |
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Principal Investigator |
坂下 英司 Jichi Medical University, 医学部, 講師 (00337320)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 選択的スプライシング / ホルモン |
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| Research Abstract |
When mouse preadipocyte 3T3-L1 cells are differentiated into adipocytes, the alternative splicing (AS) of insulin receptor (IR) is altered from exon-skipped isoform (IR-A) to exon-included type (IR-B). During the differentiation, CUGBP1, as known an alternative splicing regulator, redistributes from nucleus to cytoplasm. Our results suggest that the redistribution of CUGBP1 is not the primary cause of alternation of AS of IR.
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