2009 Fiscal Year Final Research Report
Characterization of the mechanism of biosynthesis for vitamine K dependent proteins and functional study of Vitamin K metabolic enzyme.
| Project/Area Number |
19790224
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yamagata University |
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Principal Investigator |
IWATA Hiroki Yamagata University, 医学部, 助教 (70361251)
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| Project Period (FY) |
2007 – 2009
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| Keywords | プロテインZ / ビタミンK / 生合成 / 発現調節 / ホルモン / 遺伝子多型 |
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| Research Abstract |
We characterized the 5'-flanking region of PZ gene and identified cis-acting sequences and trans-acting factors responsible for the expression of human PZ gene using HepG2. HNF-4α plays a crucial role in PZ gene expression, and that Sp1 acts as an enhancer. The levels of PZ and ZPI in plasma increased during normal pregnancy. It was suggested that the expression of PZ gene was regulated by hormones. And it was confirmed that the expression of PZ gene was enhanced by progesterone.
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