2008 Fiscal Year Final Research Report
The expression and function of CD133 in cancer cells
| Project/Area Number |
19790240
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kinki University |
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Principal Investigator |
ARAO Tokuzo Kinki University, 医学部, 講師 (20441074)
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| Research Collaborator |
NISHIO Kazuto 近畿大学, 医学部, 教授 (10208134)
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| Project Period (FY) |
2007 – 2008
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| Keywords | CD133 / がん幹細胞 / 分子腫瘍学 |
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| Research Abstract |
がん細胞の幹細胞マーカーCD133の発現は、mTORシグナル阻害により発現が誘導され、低酸素およびHIF-1A誘導剤により発現が著明に抑制されることを見出した.本研究によりCD133発現制御メカニズムは、HIF-1Aを介して抑制的に制御されていることを初めて明らかにした.この研究はがん幹細胞の発生初期のシグナル伝達およびがん幹細胞機能維持の原因解明につながる手がかりになると考えられる.
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[Journal Article] Circulating endothelial cells in non-small cell lung cancer patients treated with carboplatin and paclitaxel2009
Author(s)
Kawaishi M, Fujiwara Y, Fukui T, Kato T, Yamada K, Ohe Y, Kunitoh H, Sekine I, Yamamoto N, Nokihara H, Watabe T, Shimoda Y, Arao T, Nishio K, Tamura T, Koizumi F
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Journal Title
J Thorac Oncol 4(2)
Pages: 208-13
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[Journal Article] Identification of Predictive Biomarkers for Response to Trastuzumab Using Plasma FUCA Activity and N-Glycan Identified by MALDI-TOF-MS2009
Author(s)
Matsumoto K, Shimizu C, Arao T, Andoh M, Katsumata N, Kohno T, Yonemori K, Koizumi F, Yokote H, Aogi K, Tamura K, Nishio K, Fujiwara Y
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Journal Title
J Proteome Res 8(2)
Pages: 457-462
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[Journal Article] Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples2008
Author(s)
Yamada Y, Arao T, Gotoda T, Taniguchi H, Oda I, Shirao K, Shimada Y, Hamaguchi T, Kato K, Hamano T, Koizumi F, Tamura T, Saito D, Shimoda T, Saka M, Fukagawa T, Katai H, Sano T, Sasako M, Nishio K
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Journal Title
Cancer Sci 99(11)
Pages: 2193-9
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[Journal Article] Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia2008
Author(s)
Nakayama T, Hieshima K, Arao T, Jin Z, Nagakubo D, Shirakawa AK, Yamada Y, Fujii M, Oiso N, Kawada A, Nishio K, Yoshie O
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Journal Title
Oncogene 27(23)
Pages: 3221-32
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