2009 Fiscal Year Final Research Report
Epigenetic regulation of TTF-1and its differentiation-inducing properties
| Project/Area Number |
19790257
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
KONDO Tetsuo University of Yamanashi, 大学院・医学工学総合研究部, 講師 (30334858)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Keywords | 甲状腺癌 / 遺伝子 / エピジェネティックス |
|---|
| Research Abstract |
In the thyroid, Thyroid transcription factor-1 (TTF-1) is essential for thyroid organogenesis and governs thyroid functions by regulating various thyroid-specific genes. However, certain subtypes of thyroid cancers have shown low or negative expression of TTF-1. The aim of our study was to investigate the function of epigenetic modification in dysregulation of TTF-1 in thyroid carcinoma cells. Our data showed that epigenetics is involved with inactivation of TTF-1 in thyroid carcinomas, and provide a possible means of using TTF-1 as a target for differentiation-inducing therapy through epigenetic modification.
|
Research Products
(4 results)
