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2008 Fiscal Year Final Research Report

Analysis of IGFBP-4/-2expression deficiency in association with cancer progression

Research Project

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Project/Area Number 19790272
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionSt.Marianna University School of Medicine

Principal Investigator

SATO Hanako  St.Marianna University School of Medicine, 医学部, 助教 (60438132)

Project Period (FY) 2007 – 2008
KeywordsIGFBP-4 / IGFBP-2 / promoter / Hypermethylation / 癌
Research Abstract

正常細胞では増殖抑制因子IGFBP-4/-2を介したフィードバック機構が活性化することにより過剰な増殖が抑制されている。本研究では、癌化・悪性化に伴ってIGFBP-4/-2遺伝子発現制御領域にメチル化が起こることによりIGFBP-4/-2発現が減弱することを多種の癌細胞を用いて明らかにした。この事実はエピジェネティックな要因による癌細胞増殖抑制機構の破綻が普遍的に惹起されていることを示唆している。

  • Research Products

    (8 results)

All 2009 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Small Cell Lung Cancer : Significance of RB Alteration and TTF-1 Expression in its Carcinogenesis2009

    • Author(s)
      Kitamura H, Yazawa T, Sato H, Okudela K, Shimoyamada H
    • Journal Title

      Phenotype and Biology. Endocrine Pathology (in press)

    • Peer Reviewed
  • [Journal Article] Molecular and Genetitc Pathogenesis of lung Cancer : Differences Between Small-Cell and Non-Small-Cell Carcinomas2008

    • Author(s)
      Kitamura H, Yazawa T, Okudela K, Shimoyamada H, Sato H
    • Journal Title

      The Open Pathology Journal 2

      Pages: 106-114

    • Peer Reviewed
  • [Journal Article] Sex determination using mastoid process measurements : standards for Jamanese human skeletons of the medieval and early modern periods2008

    • Author(s)
      Nagaoka T, Shizushima A, Sawada J, Tomo S, Hoshino K, Sato H, Hirata K
    • Journal Title

      Anthropological Science 116

      Pages: 105-113

    • Peer Reviewed
  • [Presentation] 肺癌細胞におけるThyroid Transcription Factor-1(TTF-1)発現とTTF-l promoterのメチレーションとの関連2008

    • Author(s)
      佐藤華子、矢澤卓也、下山田博明、奥寺康司、宮田千恵、後藤和哉、石井順、榮田昌史、鈴木瞳、菅間博、北村均
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-17
  • [Presentation] 肺小細胞癌におけるIGFBP-2過剰発現メカニズムの解析および腫瘍マーカーとしての有用性に関する基礎的検討2008

    • Author(s)
      矢澤卓也、佐藤華子、下山田博明、奥寺康司、宮田千恵、石井順、後藤和哉、榮田昌史、北村均
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-15
  • [Presentation] Growth regulation viainsulin-like growth factor binding protein-4 and -2 in lung epithelialcells and cancers2007

    • Author(s)
      Sato H, Yazawa T, Shimoyamada H, Okudela K, Kitamura H
    • Organizer
      12th World Conference on Lung Cancer
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-09-04
  • [Presentation] Effects of vascular endothelial growth factors(VEGFs) on biological behavior of intrathoracic lung cancer cells2007

    • Author(s)
      Shimoyamada H, Yazawa T, Sato H, Okudela K, Kitamura H
    • Organizer
      12th World Conference on Lung Cancer
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-09-04
  • [Book] 肺癌-基礎・臨床研究のアップデートー2008

    • Author(s)
      北村均、矢澤卓也、下山田博明、奥寺康司、佐藤華子
    • Total Pages
      100-1050
    • Publisher
      日本臨休社

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Published: 2010-06-10   Modified: 2016-04-21  

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