2009 Fiscal Year Final Research Report
Identification and functional analysis of novel stem cell markers in neuronal-related cells
| Project/Area Number |
19790274
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
TAKENOBU Hisanori Chiba Cancer Center (Research Institute), 発がん制御研究部, 研究員 (60392247)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 幹細胞 / 発がん / 分化 |
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| Research Abstract |
We found that CD133 was expressed in several neuroblastoma (NB) cell lines/tumor samples. Intriguingly, CD133 repressed NB cell differentiation, accelerated cell proliferation, anchorage-independent colony formation, and in vivo tumor formation of NB cells. CD133-related differentiation suppression in NB was in part dependent on neurotrophic receptor RET tyrosine kinase regulation. RET transcription was suppressed by CD133 in NB cells and GDNF treatment failed to induce RET in CD133-expressing cells. CD133 in cancer cells and our findings may be applied to improve differentiation induction therapy for NB patients.
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[Journal Article] Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.2010
Author(s)
Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T.
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Journal Title
Oncogene. 29(18)
Pages: 2681-2690
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[Journal Article] Plk1 regulates liver tumor cell death by phosphorylation of TAp63.2009
Author(s)
Komatsu S, Takenobu H, Ozaki T, Ando K, Koida N, Suenaga Y, Ichikawa T, Hishiki T, Chiba T, Iwama A, Yoshida H, Ohnuma N, Nakagawara A, Kamijo T.
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Journal Title
Oncogene. 28(41)
Pages: 3631-3941
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